Many people including scientists are confused about the exact method of action of centrophenoxine. In several countries outside of the US it has been approved as a treatment for Alzheimer’s disease. As a nootropic supplement, it is essentially a more efficient and bioavailable form of dimethylaminoethanol (DMAE) and may have a whole other spectrum profile of cognitive effects.
Dimethylaminoethanol (DMAE) vs. Centrophenoxine
DMAE is a supplement occurring naturally in foods that is also produced naturally within the brain. It has been marketed for a large range of uses including: cognitive enhancement, anti-aging, anxiolytic and topical skin rejuvenation.
The structure of DMAE is closely related to choline which is the main precursor to the cognitive neurotransmitter, acetylcholine. There is a large debate as to whether or not DMAE acts as precursor to acetylcholine like its cousin, choline. The reason for this is because once DMAE crosses the blood brain barrier, it is thought for it to be impossible to convert into choline.
Centrophenoxine was created from the DMAE structure to be a much more efficient and bioavailable version. Like with DMAE, there is still debate as to whether or not it actually works to increase acetylcholine. One thing for certain is that there have been many studies to show the effectiveness of centrophenoxine at increasing cognitive performance however ost of these studies have been targeted towards older and diseased (Alzheimer’s) patients.
Overall when comparing the benefits of DMAE and centrophenoxine, the latter will win both in terms of cognitive benefits, as well as bioavailability. If you are already supplementing DMAE as a nootropic, centrophenoxine may offer advanced benefits to your nootropic stack.
Most of the studies pertaining to centrophenoxine have taken place in aging mammalian brains but it may also have benefits to the young or in those without neurological dysfunction. It is widely considered to be a powerful antioxidant, which may boost the overall goals of many nootropic users. After all, many nootropic users’ goals is not just to temporarily increase brain function, but to also reduce brain aging and increase overall cognitive health in the long run.
Many of the studies involving centrophenoxine have involved aging or diseased mammal brains. A large amount of the studies have shown the nootropic to reduce or slow down the progress of aging and decrease damages to the cholinergic system. Other studies have also shown both centrophenoxine and DMAE to be beneficial in those with certain brain injuries/trauma.
Although the method of action may not be entirely clear, it may be possible that centrophenoxine increases acetylcholine and/or cholinergic activity through alternate methods. One study did show that the nootropic increased choline levels in rat brains. Increasing the rate of choline or acetylcholine synthesis by increasing or freeing up phospholipids may be entirely possible. One thing for certain is that centrophenoxine may have benefits as an antioxidant and supporting nootropic in both young and old users.
Centrophenoxine Stacking – Can (Should) It Be Used With Choline?
The main question many people have is whether or not centrophenoxine should be used with choline or an acetylcholine supplement like alpha GPC or citicoline. Centrophenoxine and DMAE may be related to choline but the two substances are NOT the same. Centrophenoxine can be stacked with choline and should not replace a normal choline or acetylcholine supplement regimen.
Centrophenoxine or DMAE may even help to increase choline and acetylcholine synthesis in some way. This of course has not been proven in humans however in rat brains centrophenoxine increased the overall amount of choline. Adding this nootropic may improve the efficacy of an already established choline or acetylcholine supplement stack.
Several choline-related supplements such as acetyl L-carnitine may compliment acetylcholine synthesis. ALCAR and choline is thought to be a great combination. The ALCAR acts not as a precursor to choline itself, but as a synthesis aid to acetylcholine (helps choline convert into acetylcholine). Centrophenoxine may have benefits similar to ALCAR when used in conjunction with a choline or a choline related supplement.
So centrophenoxine may be used in a nootropic stack with choline or acetylcholine supplements. Like ALCAR, it is not considered to be a choline supplement itself however it may have cholinergic effects. There are also other things to consider in your stack. Centrophenoxine has anti-oxidant effects and adding it to your already robust stack may not be a bad idea for alternative health benefits.
Centrophenoxine is a great nootropic and anti-oxidant that is widely misunderstood. It has actually grown in popularity as a nootropic over the years and may people are using it as a more advanced form of DMAE. Its’ potent anti-oxidant activity make it an attractive supplement to add into a stack.
Centrophenoxine may be used in a cholinergic stack and is not meant to replace a choline source. This is not to say it may not increase cholinergic-related side effects by any means. Having this supplement added to your regimen may help to add benefits and its popularity has steadily been increasing over the years.