Today we are going to review Phenibut. What is it? Is it a nootropic or an anxiety supplement? The truth is that phenibut is not a nootropic. Generally, most effective anxiolytics (anti-anxiety) drugs and supplements do not boost cognitive function because they have effects on different neurotransmitters (GABA).
So Why Take Phenibut?
The reason we sell phenibut in our store is because many people like to add it to their nootropic stacks to help reduce stress and anxiety. Most of our customers are students and professionals. These people take phenibut for the same reasons – to help take the edge off in their tasks and activities.
Many people who take nootropics are already in stressful environments due to the demanding activities of their studies and careers. Using phenibut to reduce stress not only has personal benefits, but can also add to the overall benefits of a nootropic stack by reducing corticosteroids and promoting sleep.
Stress may cause negative effects on how cholinergic nootropics like the racetams work but raising counterproductive corticosteroids. In essence, for optimal racetam performance, one should be in a relaxed state of mind. Another negative effect of stress is sleep deprivation, which can really affect cognitive performance. Phenibut itself can be used as a sleep aid to help during stressful times which is another common use of the supplement.
How to Use Phenibut – Cycling to Reduce Tolerance
There are some strict rules for using phenibut properly. It is not something to be abused. It can build tolerance rather quickly when used consecutively and especially in higher dosages. It is a supplement to be respected and used in moderation. Do not rely on it to be a daily anxiolytic or sleep aid.
For the best results of phenibut, it is recommended to cycle whether or not you are using it alone or in a nootropic stack. Cycling consists of using the supplement for a few days and then taking a few days off. This will reduce tolerance and keep the supplement working long term. A rule of thumb is to not use phenibut for more than three days a week and keep proper spacing in between dosages. Others may use it consecutively for a week and then take a week or two off to lower their tolerance again
How Phenibut Works
Phenibut works as a non-selective GABA agonist but primarily affects the GABA-b receptors. A drug or supplement that activates a type of receptor is known as an agonist whereas a positive allosteric modulator amplifies the signal of a receptor. For instance, benzodiazepines work as positive allosteric modulators of GABA receptors.
Both phenibut and benzodiazepines affect GABA receptors but the later primarily affects GABA-a receptors. Phenibut being an agonist of GABA-b rather than a positive allosteric modulator of GABA-a, makes it have a much less addictive and safer than benzodiazepines.
Dosage of Phenibut
By working as an agonist of GABA receptors, phenibut has anxiolytic, sedative, hypnotic and muscle relaxant properties. The effects of each depend largely on dosage of phenibut. Lower dosages will yield anxiolytic and slight muscle relaxant properties. These dosages are around 500-750mg but may need to be lowered if you are naturally sensitive to phenibut.
Higher phenibut dosages may yield actual intoxication. Phenibut intoxication may exhibit noticeable effects slightly similar to alcohol intoxication. You should not drive or operative machinery when taking phenibut in high dosages. High dosage phenibut may also cause either a slight “afterglow“ or hangover the next day depending on the person. High dosages can be 750mg to 3000mg and going to the higher spectrum can have more side effects.
Precautions for Phenibut Use
You should never mix phenibut with a GABA/GHB agonist or GABA positive allosteric modulator. The consequences can range from non-threatening side effects, to potential life threatening problems. Mixing phenibut with alcohol will likely potentiate the effects of both leading to faster and more intense intoxication. Combining phenibut with benzodiazepines or GHB is considered dangerous and may promote respiratory depression in high dosages which can be life threatening without prompt medical aid.
Phenibut can be a great anxiety and sleep aid when used properly. It is a recommended supplement to try if you are experiencing temporary stress, anxiety or insomnia. It can be used strategically in a nootropic stack to help accommodate stress reduction and sleep. Just remember to follow our tips and use with care.