The Difference between Alpha GPC & CDP Choline
People are often stuck choosing between alpha GPC and CDP Choline (citicoline). The prices and dosages are similar for both supplements and both work to improve the level of acetylcholine. This article will outline some of the features of both as well as the pros and cons of choline and acetylcholine supplements.
Choline vs. Alpha GPC vs. Citicoline
Choline is the precursor to the neurotransmitter acetylcholine and can be obtained from foods in the form of phosphatidylcholine. It can also be obtained as a supplement in the form of choline bitartrate and other salt forms such as citrate which are commonly taken as supplements in conjunction with racetam nootropics.
People often supplement choline bitartrate and phosphatidylcholine with nootropics because they are cheap. Boosting acetylcholine may help potentiate the effects of nootropics and these two supplements are the best bang for your buck. Unfortunately, neither supplement has nootropic, dopaminergic or neuroprotective qualities.
Supplementing choline can have many benefits however the brain may not always convert choline into acetylcholine. There are many factors and complicated mechanisms that take place within the cholinergic system. How acetylcholine is synthesized and released in different parts of the brain may be affected by different things and be dependent on the person’s chemistry.
Alpha GPC and citicoline have very different mechanisms however both work to increase the level of acetylcholine. A main difference between these supplements and choline or phosphatidylcholine is that they are considered to be nootropic on their own. Both alpha GPC and citicoline are superior to choline and phosphatidylcholine in terms of effectiveness and side effects. Choline appears to have more side effects including depression and headaches (which is not to say alpha GPC and citicoline cannot cause these same problems).
One other difference between alpha GPC, citicoline and choline is the different neurotransmitters that are affected. Choline specificialy acts as prescursor to acetylcholine whereas alpha GPC and citicoline both affect dopamine. Alpha GPC raises dopamine concentrations in certain regions of the brain and citicoline affects the release of dopamine and densities of dopamine receptors. These multiple dopaminergic mechanisms of alpha GPC and citicoline may contribute to their nootropic benefits.
Alpha GPC vs. Citicoline Mechanisms
Citicoline has unique and specific mechanisms. Once in the digestive tract, it converts into choline and then back into citicoline when through the blood brain barrier. It works to drastically increase the rate of choline synthesis as well as to replenish depleted levels of phosphilipids which has positive effects on acetylcholine release and synthesis.
Alpha GPC on the other hand, is a natural substance found in foods and within the body. Supplementing with alpha GPC has been shown to have benefits on cognitive functioning, especially in those with cholinergic defects. Alpha GPC has an almost opposite mechanism to citicoline. Instead of acting as an intermediate in acetylcholine production, it instead catabolizes into acetylcholine.
Both Alpha GPC and citicoline have dopaminergic effects which can positively affect cognition. Alpha GPC has been demonstrated to increase dopamine concentrations within the cerebellum and frontal cortex of rat brains. It has also been demonstrated to enhance dopamine release from neurons in certain circumstances. Citicoline also may encourage dopamine release by encouraging tyrosine hydroxylase activity and may act as a partial dopamine reuptake inhibitor.
Which Is Better?
Alpha GPC and citicoline both may have nootropic qualities as well as an abundance of other health benefits. Both are far superior to any other choline supplement. Which is better depends on personal choice and there seems to be a divide between the two. On our site, both sell extremely well but we see slightly higher sales of alpha GPC overall. This does not mean alpha GPC is better than citicoline.
Choosing between alpha GPC and citicoline may be a difficult choice. For this reason, we recommend to try both. If cost is your main concern, citicoline is cheaper to produce and may be better for long term cost savings. Regardless of your choice, choosing alpha GPC or citicoline to stack with your racetams is a superb pick.
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