Phenylpiracetam, also known as Carphedon and Phenotropil, is an analogue of the classic nootropic compound piracetam. The compound possesses the same 2-oxo-pyrillidinone skeleton that all racetams share. The only real difference between it and it’s parent compound piracetam is the addition of a phenyl chain. In addition to making it much stronger at lower doses it’s also reportedly more neuroprotective than piracetam as well as being more apt to increase physical performance and output and even cold resistance.
There is only a single rat study currently that seems to show cognitive enhancement in otherwise healthy, young rodents however this study used the R-isomer form (a racemic mixture which is what is generally sold as a supplement). There is some controversy as to whether the cognitive enhancing effects of phenylpiracetam are limited to the aged, or even only in aged with natural cognitive decline (as opposed to traumatic brain injury for instance) or whether improvement in certain tests might be attributed primarily to the psychostimulatory properties of phenylpiracetam.
Average dosage for phenylpiracetam ranges from 100-200mg and this dose is to be taken up to 2 to 3 times per day for a total daily dosage not to exceed 200-600mg. An optimal dosage range has not been discovered but since it works well in the lower range and has a possibility of causing tolerance to build it is recommended that the minimum effective dose be used.
THINGS TO REMEMBER WITH PHENYLPIRACETAM
Due to it’s effect on increasing physical endurance, output and cold resistance it’s banned by the World Anti-Doping Agency as a performance enhancer so it should be avoided by professional athletes.
Phenylpiracetam is not only one of the strongest racetams, but also one of the speediest. Insomnia is a common side effect when taken in too high doses or too late in the day or can be an issue to those who are especially sensitive to stimulants. As with many racetams, headache and brain fog can occur if the person doesn’t have levels of vesicular acetylcholine sufficient to meet the upmodulated demand of acetylcholine production. Choline bitartrate and choline citrate are possible choices but Alpha GPC and citicoline are higher quality precursors.
Phenylpiracetam is banned by the World Anti-Doping Agency (Olympics) due to its reported psychostimulatory and cold resistance properties as a result it should be avoided by anyone who competes professionally in any type of sports.
Another thing to remember is that tolerance to phenylpiracetam can build rapidly. Sticking to the minimum effective dose and only using it two to three times per week is recommended as a result. Despite some rare anecdotal reports of depression associated with use of phenylpiracetam there is some Russian research that shows it may actually be beneficial to those dealing with mild depressive symptoms. It may be possible to “reset” tolerance to the stimulant effects of phenylpiracetam using NMDA glutamate receptor antagonists such as mild agonist magnesium threonate or the more potent NMDA agonist and Alzheimer’s drug and nootropic memantine. NMDA is an important endogenously produced compound as far as learning and memory are concerned. As with any supplement, always check with your personal care practitioner especially if you are currently under a doctor’s care or taking any over-the-counter or prescribed medications.
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