3 reviews

$24.99 From: $19.99

50 – 100 grams

  • Improve Memory
  • Acetylcholine Source
  • Synergistic With Racetams

Looking for Centrophenoxine Capsules?


SKU: 8 Category:


Recommended Dosage: 250-500mg
Directions: Centrophenoxine is water soluble.  Recommended to take with food 1-2 times daily.  Do not use if you are pregnant/breastfeeding. Extremely rare side effects may include allergic reactions. Consult a doctor prior to using. By using our products, you agree to our terms & conditions.
Warning: Centrophenoxine might cause birth defects. Those pregnant, breastfeeding or planning to become pregnant should avoid using Centrophenoxine

Centrophenoxine is made from DMAE. DMAE is a natural chemical that has been shown to improve areas of cognition and mood. DMAE’s exact method of action is slightly disputed. Some see it as a precursor to Acetylcholine but others contest this as choline molecules broken down from DMAE are not believed to cross the blood-brain-barrier efficiently.

DMAE vs. Centrophenoxine

It is not clear how the method of action differs from DMAE to Centrophenoxine. One thing for sure is that Centrophenoxine is much stronger than DMAE as a nootropic. This is likely due to a higher bioavailability of Centrophenoxine or a difference in how it is metabolized in the liver. If you are taking DMAE as a choline source, consider switching to Centrophenoxine as it is known to be more powerful as a nootropic substance.

Both substances are broken down in the liver. The liver metabolizes both substances and breaks them down into choline or phospholipid molecules. DMAE has been suggested to have limited effectiveness because the choline molecules are charged and therefore have limited effectiveness in getting to the brain.

Centrophenoxine Method of Action

Choline and certain phospholipids are converted into Acetylcholine. Acetylcholine is important and higher levels and receptor uptake will lead to better cognition. Not all choline will be converted into Acetylcholine and there are several processes that take place between the choline to Acetylcholine conversation. It seems as not all choline sources are created equal. Some sources will have much higher levels of Acetylcholine conversion.

Centrophenoxine’s primary method of action is believed to be caused by increased levels of Acetylcholine. Whether this is from breakdown into choline or related phospholipids’ is unclear. There are several phospholipids that will also convert into Acetylcholine. This may be an area where Centrophenoxine is more superior to DMAE. With this said, the general consensus is that Centrophenoxine supplementation leads to higher Acetylcholine levels and better cognition.

Centrophenoxine also may have effects on other neurotransmitters in the brain. It has been suggested to help with mood. This may be due to effects on Serotonin and Dopamine. This is speculation and we were not able to find research to back this up.

Potential Benefits

Centrophenoxine has been marketed under trade names such as “Lucidril”. In medical science, Centrophenoxine has been shown to help with age related cognitive decline under some circumstances. Centrophenoxine may also help with mood and hyperactivity.

Centrophenoxine is also an excellent antioxidant. It helps to reduce free radicals in the brain. It is more superior to DMAE as an antioxidant. For this reason, Centrophenoxine has been promoted to reduce “brain aging” and is marketed primarily as a powerful antioxidant.

Possible Side Effects

Centrophenoxine has been seen to be well tolerated. Although this is true, side effects can still occur. These side effects are more likely in higher doses and when combined with other substances. If you are on prescription drugs you should speak with your doctor to assist in avoiding interactions with Centrophenoxine. Below are some common side effects of Centrophenoxine.

  • Headache
  • Nausea
  • Dizziness
  • Gastronintesinal issues
  • Jaw clenching
  • Irritability

If you do experience side effects it is recommended to discontinue use and speak to a physician.

Centrophenoxine vs. Alpha GPC vs. CDP Choline

Centrophenoxine, like Alpha GPC and CDP Choline is an excellent Acetylcholine source. Comparing the three is very hard as it comes down to personal experimentation to find the best supplement for you. If you are using nootropics like racetams, an Acetylcholine source will often be added to potentiate effects. Centrophenoxine, Alpha GPC or CDP Choline may all be options for you. These three options are the best choices for choline supplementation.

You may experience headaches with any of these three but the chance is much less than with other choline sources. Alpha GPC or CDP Choline may cause headaches and Centrophenoxine may not or vise-versa. Alternatively, one may cause depression and another may put you in a better mood. All of these outcomes have been experienced. In the end, try one you like and stick with it.


These statements have not been evaluated by the FDA.  This product is not intended to diagnose, treat, cure, or prevent any disease.

Additional information

Weight 75 g
Dimensions 6.75 × 4 × 1.6 in

50, 100


  1. :


    This is one of the best nootropics available, probably my very favorite. It’s one of the very few that you can actually feel working the first day. I never want to be without this one!

  2. :


    Fast shipping and fantastic customer service! Will definitely order again!

  3. (verified owner):


    I started trying centrophenoxine to complement other drugs being taken for a variety of historic head trauma. The effect has been incredible. Where I was barely able to function before, now my mood has improved and my headaches are almost gone. Additionally, many of the side effects I had before, such as loss of appetite went away. Finally approaching normal.

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