Pramiracetam is a derivative of Piracetam, which is the original nootropic. Pramiracetam was first developed in the 1970s, and it is much stronger than Piracetam. In fact, it is believed that Pramiracetam capsules are up to 30 times more potent than Piracetam, and this makes them popular amongst advanced nootropic users. It is recommended in most cases to stack a choline supplement with Pramiracetam for optimal results.
Mechanism of Action
The method of action that is displayed by this newer racetam is comparable to other nootropics within this same family line. This product is believed to work by improving the efficiency of Acetylcholine. The primary mechanism of Pramiracetam capsules are believed to be related to choline uptake also known as, high affinity choline uptake (HACU).
Pramiracetam capsules seem to affect the hippocampus by influencing its choline uptake. Research has not found any other areas of the cerebral cortex that are impacted by Pramiracetam. Therefore, it is believed that this nootropic only influences specific hippocampus nerve impulses and Acetylcholine uptake which leads it to its potentially powerful effects on learning and memory.
- May Improve Long-Term and Working Memory
- Might Increase Technical and Logical Thinking
- May Increase Ability to Focus and Learn
- Possibly Improve Sensory Perception
- Potential Study Nootropic
Possible Side Effects
Just like any other nootropic capsule, there could be instances of side effects. Headaches are common, and have been associated with altering levels of cholinergic activity. This side effect might be reduced with choline supplementation or with a reduction in Pramiracetam dosage however if it persists, it is recommended to discontinue use and consult a doctor.
Brain fog, lethargy and irritability are also common side effects that may be a result of Pramiracetam’s effects on other neurotransmitter systems. If you experience these side effects, you should cease pramiracetam supplementation immediately.
Pramiracetam is a strong nootropic and side effects are more common, especially during higher dosing. You should test your sensitivity to this supplement in low dosages before increasing. Generally, Pramiracetam capsules are very well tolerated however, instances of allergic reactions are possible. These side effects, although rare, should be monitored and a doctor should be consulted immediately if you develop concerning conditions.
There are limited reports of Pramiracetam drug interactions however, one should consult a medical professional if they are on other medications. Generally, this nootropic is very well tolerated and interactions are extremely uncommon. The user should still take the necessary precautions to avoid an interaction. Women who are pregnant or breastfeeding should avoid taking this nootropic.
Although it is still just a theory, there have been some studies conducted which point to the idea that Pramiracetam capsules affect the hippocampal ACh receptors by increasing choline uptake. It is believed that this is the main culprit behind common side effects such as fatigue and headaches. The theory is that too much Acetylcholine and choline are used up in the body. This may lead to headaches and other side effects, however this has not been officially confirmed and should be avoided as direct advice.
Many people stack Pramiracetam capsules with choline for multiple reasons. One theory is that this stack has synergistic effects because choline may be modulated by Pramiracetam. Most people will use Alpha GPC or Citicoline in place of choline itself for a more advanced nootropic supplement with similar properties. Generally, Pramiracetam is used as the sole racetam in this stack however, it is possible to add in other racetams and nootropics as well.
The Pros and Cons of Choosing Pramiracetam Capsules
Nootropic capsules have several benefits over the powder version. The main advantage the powder version of this supplement has is a lower price point, but the convenience of using capsules far outweighs this perk for many people. In fact, measuring the exact quantities needed is a time-consuming process with powder. Pramiracetam powder is also fat soluble, so measuring and consuming it may seem tricky for some users. Taking Pramiracetam in capsule form will also allow the user to avoid the unpleasant after-taste of this nootropic supplement.