Well, it is yet another year and another new list of the top nootropics has been released, the top nootropics in 2017. This list has been carefully created by Peak Nootropics staff based on the data from our top selling products as well as from external trends we have observed. Like in previous years, efficacy, tolerability and price are the three most important factors to determine this list.

#1 Noopept

Noopept makes #1 on the list of best nootropics in 2017, which is no surprise given its prior performance. Primary things impacting noopept’s maintaing its ranking in 2017 are two-fold. First, this nootropic has always been on the list of previous years because it consistently performs in its role. And second, the price relative to performance has been a prominent factor in determining where noopept sits on this list each year.

Noopept works as a strong cholinergic nootropic that acts as an acetylcholine positive allosteric modulator. This mechanism greatly enhances the signal of the acetylcholine neurotransmitter at the receptor. For those that do not know, acetylcholine is responsible for a host of cognitive functions. Unlike some other cholinergic nootropics in the racetam class, noopept has an extremely high bioavailability meaning it can achieve its effects at a much lower dosage. This means that taking the powder can be convenient and easy with the right measuring devices.This adds increased value and convenience when supplementing this nootropic.

#2 Piracetam

As in previous years, piracetam has again made the list of top nootropics in 2017. Even though piracetam has been at battle with newer more advanced nootropics, it has still remained very popular and we don’t see that changing anytime soon. Piracetam is the most studied racetam so people have a lot of trust and confidence in it. Piracetam is also very stackable and can be combined with a host of other nootropics, which along with widespread availability makes it the leader in this category. It is also a great starting nootropic for beginners.

Piracetam affects cholinergic and glutamatergic receptors, both of which are suggested to play a major role in cognitive functioning. As with noopept, piracetam acts as a modulator at acetylcholine receptors. Aside from this, it also has a role in modulating AMPA and NMDA glutamate receptors. Both of these mechanisms are believed to play a role in its nootropic effects. Piracetam is also very affordable however the price hasn’t dropped much over the years because it is already cheap and widely available.

#3 Aniracetam

Aniracetam has moved up in popularity in the past year and makes its debut on the list of top nootropics for 2017. Affordability seems to be a major driver in the move up in popularity, with significant usage by students.  Given its reputation for reliable results, in combination with cost its popularity can be understood.

Aniracetam is considered a fairly safe and low toxicity substance to improve cognition and memory or reduce anxiety symptoms. Like other racetams, it can have an added benefit of reducing free radicals and oxidative stress in the brain which can lead to degenerative diseases and neurological complications.  It should not be used as a main line of defence or treatment for degenerative diseases like Alzheimer’s and Dementia but may have merit in reducing some of the symptoms associated.

#4 Phenibut

In a strong performance for the year, continuing into the new year, phenibut has made the list of top nootropics in 2017. Phenibut can have a host of benefits when used properly. On the flip-side, using improperly can result in a negative experience that may turn one off from the substance for good. The benefits of phenibut often relate to calmness and a reduction in anxiety. Phenibut may also help to reduce stress and encourage a better sleep.  Finding a “sweet spot” where one can feel the full effects of relaxation without impairing their mental function is how most nootropic users take phenibut.

Generally, phenibut shares similar pharmacological effects as GHB, Baclofen and alcohol. Higher dosages can lead to an “intoxication” that may inhibit the central nervous system. Lower dosages of phenibut can yield calm-inducing and relaxant effects. Mixing phenibut with other GABA agonists can cause synergistic and cross-cumulative effects that can be dangerous. This should be minimalized or avoided altogether.

Phenibut is a substance that can have excessive side effects and safety concerns if used improperly. It is generally considered much safer in low doses. Phenibut shares similar side effects with other GABA substances.  Mixing phenibut with other GABAergics can cause more severe consequences. Respiratory depression can be a serious side effect that may result in death. Mixing phenibut with GHB and certain benzodiazepines may cause the respiratory depression which can cause unconsciousness and death. Mixing phenibut with alcohol can increase the chance of blackouts and unconsciousness.

#5 Alpha GPC (99%)

Alpha GPC is yet another popular nootropic that is making a repeat from the list in 2016 here again in 2017. This nootropic is generally stacked or combined as a synergetic supporting nootropic amongst cholinergic racetams. Alpha GPC is found naturally within the brain and within certain foods. Alpha GPC powder can come in the 99% and the 50% versions although, the 99% version is rarely seen in capsules due to the extreme difficulty of encapsulation. Therefore, buying 99% powder is a good way to take alpha GPC because the powder is water soluble and does not have a very strong taste.

When Alpha GPC is consumed it has a range of biological functions. It’s end by-product of metabolism is both acetylcholine and phospholipids. In this sense, it is technically not a precursor to acetylcholine like choline itself however, supplementation is generally believed to increase free acetylcholine via its metabolism.

 

Honorable Mention

Natural nootropics have been growing in popularity in the past year and some came close to making the list in 2017.  Included among those are rhodiola rosea, phenylethylamine (PEA), and the stack of caffeine with l-theanine (green tea extract).   These products provide many nootropic benefits, with the added plus that they are not synthetically produced.  For many people this is their strongest support.

Considerable growth has been seen with these products, due to the energy and mind enhancing properties experienced by many users.

Conclusion

We really hope you enjoyed our list of top nootropics in 2017. This list has been carefully thought out in order to give you some suggestions and feedback. We have a lot more information on our blog about each of these nootropics. In the end, you should consider effectiveness, price and safety as all major factors when choosing a nootropic or stack. All nootropics effect everyone differently and some have good effects while others may have side effects. No nootropic comes without risk so you should consider this when making a choice as it should always be your number one concern.

 

See the list from 2016
See the list from 2015
See the list from 2014